Category Archives: Microglia

Involvement of innate immunity in the development of inflammatory and autoimmune diseases.

July 28, 2010 – 12:44 pm

<Note: The nature of wheat changed greatly with the Industrial Revolution as local varieties were replaced by standardized ones.> 1: Ann N Y Acad Sci. 2005 Jun;1051:787-98. Involvement of innate immunity in the development of inflammatory and autoimmune  diseases. Tlaskalová-Hogenová H, Tucková L, Stepánková R, Hudcovic T, Palová-Jelínková L, Kozáková H, Rossmann P, Sanchez D, [...]

By Rick | Also posted in Abstracts, Cascade, Causes, Gastrointestinal System, History of PD, Immune System, Inflammation, Living With PD, Neuroinflammation, Processes, Uncategorized, Wheat Gluten | Comments (0)

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease.

July 28, 2010 – 11:41 am

<Note: Iron triggers aggregation of alpha-synuclein.> 1. FASEB J. 2005 Apr;19(6):533-42.  Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J.  Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute [...]

By Rick | Also posted in Abstracts, Alpha-Synuclein, Causes, Immune System, Inflammation, Neuroinflammation, Processes | Tagged | Comments (0)

Analogies and Understanding PD

February 17, 2010 – 12:33 pm

PD is a complex creature and difficult to understand. One way to overcome this problem is by using analogies to make it comprehensible. If a picture is worth a thousand words, then a good analogy is just as valuable. One major feature of YOPD is the struggle to maintain homeostasis, or balance, in the mind [...]

By Rick | Also posted in Cascade, Causes, Endocrine System, Immune System, Inflammation, Neuroinflammation, Stress Response, Systems and PD, Three Faces of PD, Uncategorized | Comments (0)

About PD

February 12, 2010 – 3:50 pm

Tutorials and General Instruction – Arranged from Beginner to Advanced, more or less. The Human Brain From the Franklin Institute, this has to be one of the best on our subject and is particularly directed at the beginning student. It is also one of the best designed sites on the web. BBC The Human Body [...]

By Rick | Also posted in Cascade, Causes, Commentary, Endocrine System, Immune System, Inflammation, Nervous System, Neuroinflammation, Rants and Raves, Stress Response, Systems and PD, The Big Picture, Uncategorized | Comments (0)

Cascade – Inflammation and Immune Factors

February 8, 2010 – 12:12 pm

(This post references the graphic entitled “The Parkinson’s Cascade” found here.) Just as Young Onset Parkinson’s Disease can have a part of its origin in fetal exposure to maternal stress, so too does it arise from a similar exposure to problems with “Maternal Health” and particularly the products of maternal infection. Like the exposure to [...]

By Rick | Also posted in Cascade, Causes, Endocrine System, Environment, Immune System, Inflammation, Lipopolysaccharide (LPS), Nervous System, Neuroinflammation, Processes, Uncategorized | Comments (0)

Neuroinflammation – Summary

September 15, 2009 – 7:45 pm

Over the last few weeks it has been somewhat like the clouds have parted and a new understanding of Parkinson’s Disease has emerged. While a great deal of research on the role of inflammation has long been available, it has been one of a number of possible explanations. It has now moved from the “possible” [...]

By Rick | Also posted in Cascade, Causes, Immune System, Inflammation, Neuroinflammation, Processes, Three Faces of PD | Comments (0)

Neuroinflammation: The Key- Part 5

September 8, 2009 – 10:11 pm

Today’s London “Telegraph” reported on a study in the current issue of the journal “Neurology” that pretty much seals the case for neuroinflammation as causal in both Alzheimer’s and Parkinson’s Diseases. Beginning with a group of 222 AD patients with an average age of 83, they obtained baseline data via blood work and cognitive testing. [...]

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Neuroinflammation: The Key – Part 4

August 28, 2009 – 6:49 pm

Activated microglia resemble armed sentries patrolling the perimeter of some ancient fortification. Walking along the top of the city wall in the darkness, they move quietly and with little fanfare so long as they detect no enemies. However, if they come upon an invader clambering over the parapet, the change is remarkable and instantaneous. There [...]

By Rick | Also posted in Cascade, Causes, Immune System, Inflammation, Neuroinflammation, Processes, Stress Response, Systems and PD, Uncategorized | Comments (0)

Neuroinflammation: The Key – Part 3

August 27, 2009 – 11:09 pm

Without a cause or defined course of progression for Parkinson’s Disease, it has been extremely difficult to even offer anything beyond levodopa, itself a mixed blessing. I am convinced that there is no “magic bullet”, at least not soon, because there is no single cause. This may eventually yield to the idea of treatment with [...]

By Rick | Also posted in Cascade, Causes, Immune System, Inflammation, Neuroinflammation, Processes, Systems and PD, Three Faces of PD, Uncategorized, Young Onset PD | Comments (0)

Neuroinflammation: the Key – Part 2

August 17, 2009 – 3:06 am

. Activated microglia. Alpha-synuclein aggregation. Neuronal loss in the SN. Long term persistence of effect. There is at least one other known trigger for a near identical innate immune response.  That is the effect of fetal exposure to the endotoxin lipopolysaccharide (LPS) as shown in the following reports: . 1: Exp Neurol. 2006 Jun;199(2):499-512. Epub [...]

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