<The immune and endocrine systems interact through the HPA axis.> 1: Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):555-65. Chronic inflammatory stress. Harbuz MS. University Research Centre for Neuroendocrinology, University of Bristol, UK. A major mechanism involved in maintaining homeostasis in response to chronic inflammation is the hypothalamo-pituitary-adrenal (HPA) axis, resulting in the release [...]
<Note: The nature of wheat changed greatly with the Industrial Revolution as local varieties were replaced by standardized ones.> 1: Ann N Y Acad Sci. 2005 Jun;1051:787-98. Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Tlaskalová-Hogenová H, Tucková L, Stepánková R, Hudcovic T, Palová-Jelínková L, Kozáková H, Rossmann P, Sanchez D, [...]
By Rick
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Also posted in Abstracts, Cascade, Causes, Gastrointestinal System, History of PD, Immune System, Inflammation, Living With PD, Microglia, Neuroinflammation, Uncategorized, Wheat Gluten
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<Note: Iron triggers aggregation of alpha-synuclein.> 1. FASEB J. 2005 Apr;19(6):533-42. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J. Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute [...]
February 8, 2010 – 12:12 pm
(This post references the graphic entitled “The Parkinson’s Cascade” found here.) Just as Young Onset Parkinson’s Disease can have a part of its origin in fetal exposure to maternal stress, so too does it arise from a similar exposure to problems with “Maternal Health” and particularly the products of maternal infection. Like the exposure to [...]
By Rick
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Also posted in Cascade, Causes, Endocrine System, Environment, Immune System, Inflammation, Lipopolysaccharide (LPS), Microglia, Nervous System, Neuroinflammation, Uncategorized
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January 17, 2010 – 1:47 am
(The following post references the chart called “The Parkinson’s Cascade” which can be viewed here.) This is one of a series of attempts to explain my view of Parkinson’s Disease in hopes of stimulating research into new areas. I freely admit to errors in this work and hope that those will be brought to my [...]
By Rick
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Also posted in Cascade, Causes, Effects, Endocrine System, Environment, Evidence, Neuroinflammation, Stress Response, Systems and PD, The Big Picture, Uncategorized, Young Onset PD
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Tagged Cascade, End
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October 15, 2009 – 1:26 pm
A Problem With Specialization Medicine has embraced the concept of “specialization” – the aquisition of knowledge that is deep but narrow. There are some obvious strengths to this approach, it is true. However, there are some major weaknesses that are not so obvious. One of the problems with this approach is that the divisional lines [...]
September 15, 2009 – 7:45 pm
Over the last few weeks it has been somewhat like the clouds have parted and a new understanding of Parkinson’s Disease has emerged. While a great deal of research on the role of inflammation has long been available, it has been one of a number of possible explanations. It has now moved from the “possible” [...]
September 8, 2009 – 10:11 pm
Today’s London “Telegraph” reported on a study in the current issue of the journal “Neurology” that pretty much seals the case for neuroinflammation as causal in both Alzheimer’s and Parkinson’s Diseases. Beginning with a group of 222 AD patients with an average age of 83, they obtained baseline data via blood work and cognitive testing. [...]
September 5, 2009 – 1:51 pm
Parkinson’s Disease is characterized by a number of ongoing processes: Neuroinflammation and Inflammation, Mitochondrial Failure, Oxidation, Microglial Activation, Altered Stress Response, Endothelial Failure, Autoimmunity, Misfolding Proteins, Excitotoxicity, – all play a role to one extent or another in the course of Parkinson’s Disease. There are almost certainly others. We really can’t understand PD without understanding, at [...]
August 28, 2009 – 6:49 pm
Activated microglia resemble armed sentries patrolling the perimeter of some ancient fortification. Walking along the top of the city wall in the darkness, they move quietly and with little fanfare so long as they detect no enemies. However, if they come upon an invader clambering over the parapet, the change is remarkable and instantaneous. There [...]