<The immune and endocrine systems interact through the HPA axis.> 1: Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):555-65. Chronic inflammatory stress. Harbuz MS. University Research Centre for Neuroendocrinology, University of Bristol, UK. A major mechanism involved in maintaining homeostasis in response to chronic inflammation is the hypothalamo-pituitary-adrenal (HPA) axis, resulting in the release [...]
<Note: The nature of wheat changed greatly with the Industrial Revolution as local varieties were replaced by standardized ones.> 1: Ann N Y Acad Sci. 2005 Jun;1051:787-98. Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Tlaskalová-Hogenová H, Tucková L, Stepánková R, Hudcovic T, Palová-Jelínková L, Kozáková H, Rossmann P, Sanchez D, [...]
By Rick
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Also posted in Abstracts, Cascade, Causes, Gastrointestinal System, History of PD, Immune System, Inflammation, Living With PD, Microglia, Processes, Uncategorized, Wheat Gluten
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<Note: Iron triggers aggregation of alpha-synuclein.> 1. FASEB J. 2005 Apr;19(6):533-42. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J. Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute [...]
February 18, 2010 – 3:28 pm
Neuroinflammation – Summary Neuroinflammation: the Key – Part 1 Neuroinflammation: the Key – Part 2 Neuroinflammation: The Key – Part 3 Neuroinflammation: The Key – Part 4 Neuroinflammation: The Key- Part 5
February 17, 2010 – 12:33 pm
PD is a complex creature and difficult to understand. One way to overcome this problem is by using analogies to make it comprehensible. If a picture is worth a thousand words, then a good analogy is just as valuable. One major feature of YOPD is the struggle to maintain homeostasis, or balance, in the mind [...]
February 12, 2010 – 3:50 pm
Tutorials and General Instruction – Arranged from Beginner to Advanced, more or less. The Human Brain From the Franklin Institute, this has to be one of the best on our subject and is particularly directed at the beginning student. It is also one of the best designed sites on the web. BBC The Human Body [...]
By Rick
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Also posted in Cascade, Causes, Commentary, Endocrine System, Immune System, Inflammation, Microglia, Nervous System, Rants and Raves, Stress Response, Systems and PD, The Big Picture, Uncategorized
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February 8, 2010 – 12:12 pm
(This post references the graphic entitled “The Parkinson’s Cascade” found here.) Just as Young Onset Parkinson’s Disease can have a part of its origin in fetal exposure to maternal stress, so too does it arise from a similar exposure to problems with “Maternal Health” and particularly the products of maternal infection. Like the exposure to [...]
By Rick
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Also posted in Cascade, Causes, Endocrine System, Environment, Immune System, Inflammation, Lipopolysaccharide (LPS), Microglia, Nervous System, Processes, Uncategorized
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January 17, 2010 – 1:47 am
(The following post references the chart called “The Parkinson’s Cascade” which can be viewed here.) This is one of a series of attempts to explain my view of Parkinson’s Disease in hopes of stimulating research into new areas. I freely admit to errors in this work and hope that those will be brought to my [...]
By Rick
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Also posted in Cascade, Causes, Effects, Endocrine System, Environment, Evidence, Processes, Stress Response, Systems and PD, The Big Picture, Uncategorized, Young Onset PD
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Tagged Cascade, End
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December 29, 2009 – 7:11 pm
A report in this morning’s Science Daily News started a cascade of its own as several pieces of the puzzle clicked into place. With the charming title of “Seeing Family for the Holidays? Scientists Discover How the Stress Might Kill You” It goes on to state “”…. researchers from the University of Connecticut Health Center [...]
October 18, 2009 – 12:26 pm
In light of the work showing a link between the flu and PD, everyone should run out and get a flu shot, right? Wrong! And maybe a very big wrong at that. As outlined elsewhere on this site, the microglia are part of the innate, hardwired defense of your brain. They hold the line while [...]
About PD
Tutorials and General Instruction – Arranged from Beginner to Advanced, more or less. The Human Brain From the Franklin Institute, this has to be one of the best on our subject and is particularly directed at the beginning student. It is also one of the best designed sites on the web. BBC The Human Body [...]