Category Archives: Causes

6-The multiple factors which initiate and influence the processes (#5) underlying PD.

Chronic inflammatory stress.

July 28, 2010 – 5:19 pm

<The immune and endocrine systems interact through the HPA axis.> 1: Baillieres Best Pract Res Clin Endocrinol Metab. 1999 Dec;13(4):555-65. Chronic inflammatory stress. Harbuz MS. University Research Centre for Neuroendocrinology, University of Bristol, UK. A major mechanism involved in maintaining homeostasis in response to chronic inflammation is the hypothalamo-pituitary-adrenal (HPA) axis, resulting in the release [...]

By Rick | Also posted in Abstracts, Endocrine System, Immune System, Inflammation, Neuroinflammation, Processes, Stress Response, Systems and PD, Uncategorized | Comments (0)

Involvement of innate immunity in the development of inflammatory and autoimmune diseases.

July 28, 2010 – 12:44 pm

<Note: The nature of wheat changed greatly with the Industrial Revolution as local varieties were replaced by standardized ones.> 1: Ann N Y Acad Sci. 2005 Jun;1051:787-98. Involvement of innate immunity in the development of inflammatory and autoimmune  diseases. Tlaskalová-Hogenová H, Tucková L, Stepánková R, Hudcovic T, Palová-Jelínková L, Kozáková H, Rossmann P, Sanchez D, [...]

By Rick | Also posted in Abstracts, Cascade, Gastrointestinal System, History of PD, Immune System, Inflammation, Living With PD, Microglia, Neuroinflammation, Processes, Uncategorized, Wheat Gluten | Comments (0)

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease.

July 28, 2010 – 11:41 am

<Note: Iron triggers aggregation of alpha-synuclein.> 1. FASEB J. 2005 Apr;19(6):533-42.  Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J.  Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute [...]

By Rick | Also posted in Abstracts, Alpha-Synuclein, Immune System, Inflammation, Microglia, Neuroinflammation, Processes | Tagged | Comments (0)

And What a Long, Strange Trip It’s Been

July 21, 2010 – 1:04 pm

<Subsonics are inaudible, extremely low frequency, yet very powerful sound waves. In nature they almost always are linked to danger and thus trigger the fight or flight response. They are also quite rare. However, in the world of the Industrial Revolution they became steadily more common. Today, millions of us live with them. Only a [...]

By Rick | Also posted in Commentary, Endocrine System, Rants and Raves, Stress Response, Systems and PD, The Big Picture, Uncategorized, Young Onset PD | Comments (0)

Wheat, Intolerance, and PD

February 20, 2010 – 2:35 pm

I want to speculate a little more than I normally would, mainly because I haven’t finished researching this topic yet. I have been thinking about wheat, of course, and that has led to some interesting questions. What if our food is trying to kill us? I don’t mean that our poor choices of fatty snacks [...]

By Rick | Also posted in Cascade, Gastrointestinal System, Immune System, Inflammation, Uncategorized, Wheat Gluten | Comments (0)

Analogies and Understanding PD

February 17, 2010 – 12:33 pm

PD is a complex creature and difficult to understand. One way to overcome this problem is by using analogies to make it comprehensible. If a picture is worth a thousand words, then a good analogy is just as valuable. One major feature of YOPD is the struggle to maintain homeostasis, or balance, in the mind [...]

By Rick | Also posted in Cascade, Endocrine System, Immune System, Inflammation, Microglia, Neuroinflammation, Stress Response, Systems and PD, Three Faces of PD, Uncategorized | Comments (0)

About PD

February 12, 2010 – 3:50 pm

Tutorials and General Instruction – Arranged from Beginner to Advanced, more or less. The Human Brain From the Franklin Institute, this has to be one of the best on our subject and is particularly directed at the beginning student. It is also one of the best designed sites on the web. BBC The Human Body [...]

By Rick | Also posted in Cascade, Commentary, Endocrine System, Immune System, Inflammation, Microglia, Nervous System, Neuroinflammation, Rants and Raves, Stress Response, Systems and PD, The Big Picture, Uncategorized | Comments (0)

Cascade – Inflammation and Immune Factors

February 8, 2010 – 12:12 pm

(This post references the graphic entitled “The Parkinson’s Cascade” found here.) Just as Young Onset Parkinson’s Disease can have a part of its origin in fetal exposure to maternal stress, so too does it arise from a similar exposure to problems with “Maternal Health” and particularly the products of maternal infection. Like the exposure to [...]

By Rick | Also posted in Cascade, Endocrine System, Environment, Immune System, Inflammation, Lipopolysaccharide (LPS), Microglia, Nervous System, Neuroinflammation, Processes, Uncategorized | Comments (0)

Cascade – Emotions and Endocrine Factors

January 17, 2010 – 1:47 am

(The following post references the chart called “The Parkinson’s Cascade” which can be viewed here.) This is one of a series of attempts to explain my view of Parkinson’s Disease in hopes of stimulating research into new areas. I freely admit to errors in this work and hope that those will be brought to my [...]

By Rick | Also posted in Cascade, Effects, Endocrine System, Environment, Evidence, Neuroinflammation, Processes, Stress Response, Systems and PD, The Big Picture, Uncategorized, Young Onset PD | Tagged , | Comments (0)

Cascade – Some Factors That Influence PD

January 15, 2010 – 6:53 pm

A case can be made for each of the factors on the chart below as either causing or influencing PD. In coming posts, this “Cascade” will be discussed section by section.

By Rick | Also posted in Cascade, Uncategorized | Comments (0)